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Advanced Search Abstract Sarcomeric dysfunction plays a central role in reduced cardiac pump function in heart failure.
This review focuses on the alterations in sarcomeric proteins in diseased myocardium that range from altered isoform expression to post-translational protein changes such as proteolysis and phosphorylation.
Novel therapies, which specifically target phosphorylation sites within sarcomeric proteins or the kinases and phosphatases involved, might improve cardiac function in heart failure. SarcomereCardiomyocyteContractilityHeart failure 1. A number of factors, including changes in cardiac structure dilation and hypertrophyapoptotic and necrotic cell death, maladaptive remodelling of the extracellular matrix, abnormal energy metabolism, impaired calcium handling, and neurohumoral disturbances have been implicated in the initiation and progression of heart failure.
Sarcomeric function is determined by the expression levels of multiple isoforms and by post-translational modifications of sarcomeric proteins. During muscle contraction a molecular interaction takes place between the thin actin and thick myosin filament of the sarcomeres, which is triggered by a rise in the intracellular calcium and is driven by the energy from ATP hydrolysis.
Alterations in sarcomeric protein composition under pathological conditions will influence contractile performance of the heart. Within the first part of this review, we discuss the functional role of individual sarcomeric protein isoforms and of post-translational protein modifications such as proteolysis and phosphorylation.
In the second part, we highlight the major changes in sarcomeric function reported in failing myocardium and discuss the most likely underlying protein modifications.Ernest O. Lawrence demonstrates the cyclotron Close To share this video via email, copy and paste the message and URL below into your favorite email client and send.
However, our results demonstrate that TALEN-mediated homologous recombination can be used to direct efficient allelic introgression in livestock without contamination of untargeted sequences and/or introduction of undesirable traits (authors, unpublished).
Basking sharks are the big, slow softies of the sea. Reaching up to 8 meters (26 feet) in length, these gentle giants cruise large stretches of the oceans simply living off plankton and the.
Care during pregnancy, labour and birth are critical to women's satisfaction with their experience and can impact their mental health in both the short and long term (Leap et al., ). A lack of control and support in labour may be associated with post-traumatic stress type symptoms (Czarnocka and Slade, ); conversely, women who reflected positively on their care reported feeling empowered (Leap .
View Matt Malouf’s profile on LinkedIn, the world's largest professional community. Matt has 7 jobs listed on their profile. See the complete profile on Industry: Management Consulting.
Malouf also demonstrates that exploring realms of the new can lead to discovery of self; a goal in life that some characters would deem to be success.
In Ransom, the notion of ‘chance’ against the norm of fate is explored; showing that a leap of faith in taking chances can lead to unexpected successes.